| NaI促进的2-吗啉基-4-芳基噻唑5-甲酸甲酯的合成 |
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| 引用本文： | 王灿,姜文清,邹建平. NaI促进的2-吗啉基-4-芳基噻唑5-甲酸甲酯的合成[J]. 苏州大学学报(医学版), 2006, 22(1): 80-82 |
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| 作者姓名： | 王灿 姜文清 邹建平 |
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| 作者单位： | 苏州大学化学化工学院 江苏苏州215123 |
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| 摘 要： | 从芳甲酸出发,经二步反应得到了芳酰基异硫氰酸酯,再和吗啉反应得到了芳酰基硫脲.在碘化钠作用下,芳酰基硫脲与氯乙酸甲酯发生成环反应,一步合成了2-吗啉基-4-芳基噻唑-5-甲酸甲酯.该方法产率高、操作简便.产物结构经1H NMR1、3C NMR及MS数据确证.
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| 关 键 词： | 碘化钠 芳酰基硫脲 氯乙酸甲酯 2-吗啉基-4-芳基噻唑-5-甲酸甲酯 |
| 文章编号： | 1000-2073(2006)01-0080-03 |
| 收稿时间： | 2005-07-15 |
| 修稿时间： | 2005-07-15 |
Synthesis of 2-morpholin-4-aryl-thiazole-5-carboxylic acid methyl ester |
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| WANG Can,JIANG Wen-qing,ZOU Jian-ping. Synthesis of 2-morpholin-4-aryl-thiazole-5-carboxylic acid methyl ester[J]. Journal of Suzhou University(Natural Science), 2006, 22(1): 80-82 |
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| Authors: | WANG Can JIANG Wen-qing ZOU Jian-ping |
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| Affiliation: | School of Chemistry and chemical Engineering, Suzhou Univ.,Suzhou 215006, China |
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| Abstract: | Aroyl thioureas were prepared by the reaction of morpholine and aroyl isothiocyanates, which were synthesized from acyl chloride and KSCN. Aroylthiourea reacted with methyl chloroacetic ester in the presence of NaI to afford 2-morpholin-4-aryl-thiazole-5-carboxylic acid methyl ester. The structures of the products were characterized by ^1H NMR, ^13C NMR and MS spectra, Furthermore, a rational mechanism was proposed for the reaction. |
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| Keywords: | Sodium iodide aroyl thiourea methyl chloroacetic ester 2-morpholin-4-aryl-thiazole-5-carboxylic acid methyl ester |
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