| 纳米孔DNA测序:我们在哪了?(英文) |
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| 作者姓名： | 梁峰 Peiming Zhang |
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| 作者单位： | College of Chemical Engineering and Technology, Wuhan University of Science and Technology;Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education,Wuhan University;The Biodesign Institute, Arizona State University |
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| 基金项目： | supported by the National Natural Science Foundation of China (21372183);the Hubei Province Natural Science Foundation (2013CFB328);the Key Laboratory of Analytical Chemistry for Biology and Medicine (Wuhan University), Ministry of Education (ACBM2014001);the Start-Up-Fund grant provided by Wuhan University of Science and Technology |
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| 摘 要： | 纳米孔DNA测序技术是一类重要的DNA测序技术,可以实现长链DNA序的快速读取.一个DNA分子可以以毫秒每碱基,甚至更快的速度通过纳米孔,从而有可能实现在1 h以内完成人类全基因组测序.与下一代DNA测序技术(next generation DNA sequencing,NGS)相比较,纳米孔DNA测序技术可以实现单分子测序,无需使用酶进行样品扩增.纳米孔DNA测序技术是后NGS时代极具潜力的DNA测序技术.本文将介绍纳米孔DNA测序技术的研究现状,并讨论在这个快速发展的领域当中面临的挑战和机遇.
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| 关 键 词： | Nanopore DNA sequencing Biological nanopores Solid-state nanopores |
| 本文献已被 CNKI 等数据库收录！ |
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