|
|||||
|
|
Dinemorphan N-demethylation by mouse liver microsomes |
|
| Authors: | P G Gervasi D Benetti L Citti M Del Monte G Turchi |
| Abstract: | Dinemorphan, an antitussive drug, is N-demethylated in vitro by mouse liver microsomes with biphasic kinetics showing two apparent Km and Vmax. Moreover, dinemorphan N-demethylation is inhibited by CO, SKF-525A, metyrapone and it is specifically catalyzed by a phenobarbital-inducible form of cytochrome P-450. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |