Involvement of ribonuclease in the interactions of macrophages and fibroblasts in experimental silicosis |
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Authors: | Sirpa Aho E Kulonen |
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Institution: | (1) Department of Medical Chemistry, University of Turku, SF-20520 Turku 52, Finland |
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Abstract: | Summary Decreased ribonuclease activity in the supernatant from silica-treated macrophages is associated with the enhanced protein synthesis in granulation-tissue slices incubated in this supernatant, and with the decreased degradation of polysomes in granuloma slices and of polysomes isolated from the granulation tissue. The phagocytized silica particles adsorb ribonuclease and perhaps other proteins and thus remove them from the macrophage supernatant.For financial support we are grateful to the Association of Finnish Life Assurance Companies and to the Medical Research Council in Finland. |
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