Amperometric detection of histamine and amino acid neurotransmitters in capillary electrophoresis with copper microelectrodes

Copper microelectrodes were used in microvoltammetry to detect histamine and several amino acid neurotransmitters. High sensitivity was obtained through the use of copper microelectrodes, and detection limits of 50 nmol/L and 90 nmol/L were obtained for histamine and histidine, respectively. Furthermore, histamine and several amino acids neurotransmitters were firstly separated and detected by capillary electrophoresis with amperometric detection on copper microelectrodes. Mass limits of 490 amol and 440 amol were achieved for histamine and histidines, respectively, by using this mothod. Supported by the National Natural Science Foundation of China Hu Shen: born in 1970, Ph. D.