| 重组人Elafin对大鼠肝脏缺血再灌注损伤的保护作用 |
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| 引用本文： | 孙任任,张赢予,赵轶卓,张馨木.重组人Elafin对大鼠肝脏缺血再灌注损伤的保护作用[J].实验动物科学,2010,27(5):23-25. |
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| 作者姓名： | 孙任任 张赢予 赵轶卓 张馨木 |
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| 作者单位： | [1]吉林大学药学院,长春130021 [2]江苏大学附属人民医院心血管病研究所,镇江212002 |
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| 摘 要： | 目的探讨重组人Elafin对大鼠肝脏缺血再灌注损伤的保护作用。方法建立大鼠肝缺血再灌注损伤模型,给予不同浓度的重组人Elafin对其进行治疗,检测血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)及乳酸脱氢酶(LDH)含量,并对肝脏病理组织学改变进行观察。结果缺血再灌注后大鼠肝组织损害较重,血清ALT、AST及LDH水平明显升高(P0.001),若手术前给予大鼠一定浓度的重组人Elafin可对肝脏缺血再灌注损伤起到一定的保护作用。结论重组人Elafin对肝脏缺血再灌注损伤有一定的保护作用。
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| 关 键 词： | 肝缺血再灌注损伤 重组人Elafin 谷丙转氨酶（ALT） 谷草转氨酶（AST） 乳酸脱氢酶（LDH） |
Recombinant Human Elafin Protects Rat Hepatic Tissue from Ischemia-reperfusion Injury |
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| SUN Ren-ren,ZHANG Ying-yu,ZHAO Yi-zhuo,ZHANG Xin-mu.Recombinant Human Elafin Protects Rat Hepatic Tissue from Ischemia-reperfusion Injury[J].Shiyan Dongwu Kexue,2010,27(5):23-25. |
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| Authors: | SUN Ren-ren ZHANG Ying-yu ZHAO Yi-zhuo ZHANG Xin-mu |
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| Institution: | 1.School of Pharmaceutical Sciences,Jilin University,Changchun 130021,China)(2.The Affiliated Hospital of Jiangsu University,Zhenjiang 212002,China) |
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| Abstract: | Objective To investigate the role of neutrophil elastase inhibitor（Elafin） in pathogenesis of hepatic ischemia-reperfusion injury（HIRI）.Methods The rat model of hepatic ischemia-reperfusion was administrated with Elafin at different doses,and then the levels of ALT,AST and LDH in serum were measured.Meanwhile,pathohistological changes in liver were examined.Results The rats showed severe hepatocytic damage after hepatic ischemia-reperfusion and serum levels of ALT,AST and LDH were significantly raised（P 0.001）.However,those symptoms could be relieved to some extent by preoperative injection of Elafin.Conclusion Neutrophil elastase inhibitor Elafin has a protective effect against hepatic ischemia-reperfusion injury in rats. |
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| Keywords: | Hepatic ischemia-reperfusion injury Neutrophil elastase inhibitor ALT AST LDH |
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