Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14 |
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Authors: | Gardner Malcolm J Shallom Shamira J Carlton Jane M Salzberg Steven L Nene Vishvanath Shoaibi Azadeh Ciecko Anne Lynn Jeffery Rizzo Michael Weaver Bruce Jarrahi Behnam Brenner Michael Parvizi Babak Tallon Luke Moazzez Azita Granger David Fujii Claire Hansen Cheryl Pederson James Feldblyum Tamara Peterson Jeremy Suh Bernard Angiuoli Sam Pertea Mihaela Allen Jonathan Selengut Jeremy White Owen Cummings Leda M Smith Hamilton O Adams Mark D Venter J Craig Carucci Daniel J Hoffman Stephen L Fraser Claire M |
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Institution: | The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. gardner@tigr.org |
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Abstract: | The mosquito-borne malaria parasite Plasmodium falciparum kills an estimated 0.7-2.7 million people every year, primarily children in sub-Saharan Africa. Without effective interventions, a variety of factors-including the spread of parasites resistant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the number of malaria cases to double over the next two decades. To stimulate basic research and facilitate the development of new drugs and vaccines, the genome of Plasmodium falciparum clone 3D7 has been sequenced using a chromosome-by-chromosome shotgun strategy. We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome. |
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