Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4 |
| |
Authors: | Feng Bing-Jian Huang Wei Shugart Yin Yao Lee Ming K Zhang Feng Xia Jian-Chuan Wang Hui-Yun Huang Teng-Bo Jian Shao-Wen Huang Ping Feng Qi-Sheng Huang Li-Xi Yu Xing-Juan Li Duang Chen Li-Zheng Jia Wei-Hua Fang Yan Huang Hui-Ming Zhu Jing-Liu Liu Xiao-Ming Zhao Yan Liu Wang-Qing Deng Mang-Quan Hu Wei-Han Wu Shao-Xiong Mo Hao-Yuan Hong Ming-Fang King Mary Claire Chen Zhu Zeng Yi-Xin |
| |
Affiliation: | Cancer Institute, Cancer Center, Sun Yat-sen University, GuangZhou, China. |
| |
Abstract: | Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both geography and genetics may influence disease risk. Although the HLA-Bw46 locus is associated with increased risk of NPC, no predisposing genes have been identified so far. Here we report the results of a genome-wide search carried out in families at high risk of NPC from Guangdong Province, China. Parametric analyses provide evidence of linkage to the D4S405 marker on chromosome 4 with a logarithm of odds for linkage (lod) score of 3.06 and a heterogeneity-adjusted lod (hlod) score of 3.21. Fine mapping with additional markers flanking D4S405 resulted in a lod score of 3.54 and hlod score of 3.67 for the region 4p15.1-q12. Multipoint nonparametric linkage analysis gives lod scores of 3.54 at D4S405 (P = 5.4 x 10(-5)) and 4.2 at D4S3002 (P = 1.1 x 10(-5)), which is positioned 4.5 cM away from D4S405. When Epstein Barr virus antibody titer was included as a covariate, the lod scores reached 4.70 (P = 2.0 x 10(-5)) and 5.36 (P = 4.36 x 10(-6)) for D4S405 and D4S3002, respectively. Our findings provide evidence of a major susceptibility locus for NPC on chromosome 4 in a subset of families. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|