The importance of the terminal hemi-acetal group for the ionophoric properties of nigericin |
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| Authors: | L. David M. Chapel J. Gandreuil G. Jeminet R. Durand |
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| Affiliation: | (1) Laboratoire de Chimie Organique Biologique, (E.R.A. 392 du CNRS) et Laboratoire de Biochimie, Université de Clermont II, B.P. 45, F-63170 Aubière, (France) |
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| Abstract: | Summary Opening of the terminal hemi-acetal in dihydronigericin drastically reduces the ionophoric properties of nigericin and dehydroxymethylnigericin with 6 intact heterocycles. This is shown by 2 complementary methods, first with a liquid membrane electrode system, secondly by testing their ionophoric activities in rat liver mitochondria.Acknowledgments. The authors are indebted to Mrs G. Kergomard for her invaluable assistance in the isolement of nigericin and to Prof. A. Kergomard for his encouragements. |
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