| 雌激素刺激脑血管内皮细胞分泌VEGF及新血管形成 |
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| 引用本文： | 闫文义,于东明,皇甫超申. 雌激素刺激脑血管内皮细胞分泌VEGF及新血管形成[J]. 河南大学学报(自然科学版), 2012, 42(1): 78-82 |
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| 作者姓名： | 闫文义 于东明 皇甫超申 |
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| 作者单位： | 河南大学医学院环境医学研究所,河南开封,475004 |
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| 基金项目： | 国家自然科学基金，省部共建河南大学科研项目 |
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| 摘 要： | 为了探讨雌激素对脑血管形成的影响,本实验利用体外培养的种植在matrigel上的脑血管内皮细胞作为模型,对雌激素刺激形成的新生血管进行照相记录,计算机软件分析.结果显示:雌激素呈剂量依赖性地刺激培养的脑血管内皮细胞分泌VEGF和新血管形成,而雄激素对培养的脑血管内皮细胞新血管形成没有任何影响;VEGF可以显著地促进内皮细胞新血管的形成.以上结果说明,雌激素通过刺激VEGF的分泌作用进而促进脑血管内皮细胞新血管的形成.
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| 关 键 词： | 血管内皮细胞生长因子 脑血管内皮细胞 雌激素 雄激素 |
Neovascularization and VEGF Secretion in Brain Microvascular Endothelial Cells Induced by Estrogen Stimulation |
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| YAN Wen-yi , YU Dong-ming , HUANGFU Chao-shen. Neovascularization and VEGF Secretion in Brain Microvascular Endothelial Cells Induced by Estrogen Stimulation[J]. Journal of Henan University(Natural Science), 2012, 42(1): 78-82 |
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| Authors: | YAN Wen-yi YU Dong-ming HUANGFU Chao-shen |
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| Affiliation: | YAN Wen-yi,YU Dong-ming,HUANGFU Chao-shen(Institute of Environmental Medicine,Medical College of Henan University,Henan Kaifeng 475004,China) |
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| Abstract: | To investigate the effects of estrogen on cerebral angiogenesis in vitro,the authors employed cultured endothelial cells planted on matrigel in the presence or absence of estrogen as model,captured the capillary-like tube induced by estrogen,and analysed with computer software.The results indicated that estrogen dose-dependently stimulates VEGF secretion and VEGF induces cerebral angiogenesis.In contrast,some dose testosterone has no significant effect.The authors concluded that estrogen stimulated cultured brain microvascular endothelial cells neovascularization mediated by the increased VEGF secretion. |
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| Keywords: | vascular endothelial growth factor(VEGF) cerebral vascular cells estrogen testosterone |
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