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人类白细胞抗原HLA—DP,DQ,DR在新疆哈萨克族食管癌中的表达及意义
引用本文:胡建明,陈云昭,刘春霞,李文婷,尹亮,康雪玲,王巍伟,刘东,梁伟华,蒋金芳,李洪安,李锋. 人类白细胞抗原HLA—DP,DQ,DR在新疆哈萨克族食管癌中的表达及意义[J]. 石河子大学学报(自然科学版), 2009, 27(6): 731-734
作者姓名:胡建明  陈云昭  刘春霞  李文婷  尹亮  康雪玲  王巍伟  刘东  梁伟华  蒋金芳  李洪安  李锋
作者单位:新疆地方病与民族高发病教育部重点实验室,石河子832002
基金项目:国家973重大基础研究前期专项,教育部科学技术研究项目,国家科技支撑计划 
摘    要:探讨人类白细胞抗原(HLA—DP,DQ,DR)在新疆哈萨克族食管鳞癌发生发展中的表达及其临床意义。采用免疫组织化学技术链霉素-过氧化物酶(S-P)法检测66例新疆哈萨克族食管鳞癌和28例正常食管粘膜组织(癌旁正常组织)中HLA—DP,DQ,DR抗原的表达。新疆哈族食管鳞癌组织中HLA—DP,DQ,DR抗原的阳性表达率为36.4%,高于正常对照组的7.1%(χ^2=8.389,P〈0.05);HLA—DP,DQ,DR抗原在食管癌中的表达与患者的年龄、性别、肿瘤生长部位、淋巴转移、分化程度无相关性。HLA—DP,DQ,DR的表达与新疆哈族食管鳞癌的发生发展密切相关。

关 键 词:HLA—DP,DQ,DR抗原  食管癌  免疫组化

Expression and Significance of Human Leukocyte Antigen HLA-DP,DQ,DR in Xinjiang Kazakh Esophageal Carcinoma
Hu Jianming,CHEN Yunzhao,LIU Chuxia,LI Wenting,YIN liang,KANG Xueling,WANG Weiwei,LIU Dong,LANG Weihua,JIANG Jinfang,LI Hongan,LI Feng. Expression and Significance of Human Leukocyte Antigen HLA-DP,DQ,DR in Xinjiang Kazakh Esophageal Carcinoma[J]. Journal of Shihezi University(Natural Science), 2009, 27(6): 731-734
Authors:Hu Jianming  CHEN Yunzhao  LIU Chuxia  LI Wenting  YIN liang  KANG Xueling  WANG Weiwei  LIU Dong  LANG Weihua  JIANG Jinfang  LI Hongan  LI Feng
Affiliation:(Education Ministry Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi 832002, China)
Abstract:Purpose to investigate the expression of human leukocyte antigen (HLA-DP, DQ, DR) and its clinical significance in Xinjiang Kazakhstan esophageal squamous cell carcinoma occurrence and development. Methods the HLA-DP, DQ, DR antigen expression of 66 cases esophageal squamous cell carcinoma and 28 cases normal esophageal mucosa (adjacent normal tissue)in Xinjiang ethnic Kazakh was detected with immunohistochemistry streptomycin-Peroxidase (SP). HLA-DP, DQ, DR antigen positive expression rate of Xinjiang Kazakhstan esophageal mous cell carcinoma is 36.4 % , higher than the normal control group of 7.1% (χ^2 = 8. 389, P 〈 0.05 ) ;there squa- is no relationship between HLA-DP, DQ, DR antigen expression in esophageal cancer patients with age, sex, tumor site, lymph node metastasis,the degree of differentiation. HLA-DP, DQ, DRexpression is closely related to the occurrence and development of Kazakhs esophageal squamous cell carcinoma.
Keywords:HLA-DP  DQ
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