| 人类白细胞抗原HLA—DP，DQ，DR在新疆哈萨克族食管癌中的表达及意义 |
| |
| 引用本文： | 胡建明,陈云昭,刘春霞,李文婷,尹亮,康雪玲,王巍伟,刘东,梁伟华,蒋金芳,李洪安,李锋. 人类白细胞抗原HLA—DP，DQ，DR在新疆哈萨克族食管癌中的表达及意义[J]. 石河子大学学报(自然科学版), 2009, 27(6): 731-734 |
| |
| 作者姓名： | 胡建明 陈云昭 刘春霞 李文婷 尹亮 康雪玲 王巍伟 刘东 梁伟华 蒋金芳 李洪安 李锋 |
| |
| 作者单位： | 新疆地方病与民族高发病教育部重点实验室,石河子832002 |
| |
| 基金项目： | 国家973重大基础研究前期专项，教育部科学技术研究项目，国家科技支撑计划 |
| |
| 摘 要： | 探讨人类白细胞抗原（HLA—DP，DQ，DR）在新疆哈萨克族食管鳞癌发生发展中的表达及其临床意义。采用免疫组织化学技术链霉素-过氧化物酶（S-P）法检测66例新疆哈萨克族食管鳞癌和28例正常食管粘膜组织（癌旁正常组织）中HLA—DP，DQ，DR抗原的表达。新疆哈族食管鳞癌组织中HLA—DP，DQ，DR抗原的阳性表达率为36．4％，高于正常对照组的7．1％（χ^2=8．389，P〈0．05）；HLA—DP，DQ，DR抗原在食管癌中的表达与患者的年龄、性别、肿瘤生长部位、淋巴转移、分化程度无相关性。HLA—DP，DQ，DR的表达与新疆哈族食管鳞癌的发生发展密切相关。
|
| 关 键 词： | HLA—DP,DQ,DR抗原 食管癌 免疫组化 |
Expression and Significance of Human Leukocyte Antigen HLA-DP,DQ,DR in Xinjiang Kazakh Esophageal Carcinoma |
| |
| Hu Jianming,CHEN Yunzhao,LIU Chuxia,LI Wenting,YIN liang,KANG Xueling,WANG Weiwei,LIU Dong,LANG Weihua,JIANG Jinfang,LI Hongan,LI Feng. Expression and Significance of Human Leukocyte Antigen HLA-DP,DQ,DR in Xinjiang Kazakh Esophageal Carcinoma[J]. Journal of Shihezi University(Natural Science), 2009, 27(6): 731-734 |
| |
| Authors: | Hu Jianming CHEN Yunzhao LIU Chuxia LI Wenting YIN liang KANG Xueling WANG Weiwei LIU Dong LANG Weihua JIANG Jinfang LI Hongan LI Feng |
| |
| Affiliation: | (Education Ministry Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi 832002, China) |
| |
| Abstract: | Purpose to investigate the expression of human leukocyte antigen （HLA-DP, DQ, DR） and its clinical significance in Xinjiang Kazakhstan esophageal squamous cell carcinoma occurrence and development. Methods the HLA-DP, DQ, DR antigen expression of 66 cases esophageal squamous cell carcinoma and 28 cases normal esophageal mucosa （adjacent normal tissue）in Xinjiang ethnic Kazakh was detected with immunohistochemistry streptomycin-Peroxidase （SP）. HLA-DP, DQ, DR antigen positive expression rate of Xinjiang Kazakhstan esophageal mous cell carcinoma is 36.4 % , higher than the normal control group of 7.1% （χ^2 = 8. 389, P 〈 0.05 ） ;there squa- is no relationship between HLA-DP, DQ, DR antigen expression in esophageal cancer patients with age, sex, tumor site, lymph node metastasis,the degree of differentiation. HLA-DP, DQ, DRexpression is closely related to the occurrence and development of Kazakhs esophageal squamous cell carcinoma. |
| |
| Keywords: | HLA-DP DQ |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
