| Construction of heteroduplex DNA and in vitro model for functional analysis of mismatch repair |
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| 引用本文： | WANGYi GlarkAlan WANGJiaxun SUNMenghong SHIDaren. Construction of heteroduplex DNA and in vitro model for functional analysis of mismatch repair[J]. 科学通报(英文版), 2004, 49(1): 3-38 |
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| 作者姓名： | WANGYi GlarkAlan WANGJiaxun SUNMenghong SHIDaren |
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| 作者单位： | [1]DepartmentofPathology,CancerHospital,FudanUniversity,Shanghai200032,China [2]LaboratoryofMolecularGenetics,NationalInstituteofEnvironmentalHealth,USA [3]ShanghaiInstituteofPlantPhysiology＆Ecology,ChineseAcademyofSciences,Shanghai200032,China |
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| 摘 要： | Functional deficiency of mismatch repair (MMR) system is one of the mechanisms of tumorigenesis. With the development of the investigation and the requirement from the clinical diagnosis and treatment it is necessary to build up a method to evaluate the functional status of the whole MMR system in the concerned tumors. The original ssDNA and dsDNA from wild type (wt) bacteriophage M13mp2 and its three derivates with mutation points in the
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| 关 键 词： | 异源双链DNA 失配校正 MMR 致肿瘤性 临床诊断 临床治疗 |
Construction of heteroduplex DNA and in vitro model for functional analysis of mismatch repair |
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| WANG Yi,Clark Alan,WANG Jiaxun,SUN Menghong , SHI Daren. Construction of heteroduplex DNA and in vitro model for functional analysis of mismatch repair[J]. Chinese science bulletin, 2004, 49(1): 3-38 |
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| Authors: | WANG Yi Clark Alan WANG Jiaxun SUN Menghong & SHI Daren |
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| Affiliation: | e-mail: smh9618 @sh163.net |
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| Abstract: | |
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| Keywords: | mismatch repair functional analysis heteroduplex DNA microsatellite instability bacteriophage neoplasms. |
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