A study on poly (N-vinyl-2-pyrrolidone) covalently bonded NiTi surface for inhibiting protein adsorption |
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| Authors: | Hongyan Yu Yang Liu Yajie Wang Li Liu Bolong Li Yan Li Xinqing Zhao |
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| Affiliation: | School of Materials Science and Engineering, Beihang University, Beijing 100191, China;Beijing Research Center for Radiation Application, Beijing Key Laboratory of Radiation Advanced Materials, Beijing 100015, China;Core Laboratory of Clinical Medical Research, Department of Clinical Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;Core Laboratory of Clinical Medical Research, Department of Clinical Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;Beijing Research Center for Radiation Application, Beijing Key Laboratory of Radiation Advanced Materials, Beijing 100015, China;School of Materials Science and Engineering, Beihang University, Beijing 100191, China;School of Materials Science and Engineering, Beihang University, Beijing 100191, China |
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| Abstract: | Near equiatomic NiTi alloys have been extensively applied as biomaterials owing to its unique shape memory effect, superelasticity and biocompatibility. It has been demonstrated that surfaces capable of preventing plasma protein adsorption could reduce the reactivity of biomaterials with human blood. This motivated a lot of researches on the surface modification of NiTi alloy. In the present work, following heat and alkaline treatment and silanization by trichlorovinylsilane(TCVS), coating of poly(N-vinyl-2-pyrrolidone)(PVP) was produced on the NiTi alloy by gamma ray induced chemical bonding. The structures and properties of modified NiTi were characterized and in vitro biocompatibility of plasma protein adsorption was investigated. The results indicated that heat treatment at 823 K for 1 h could result in the formation of a protective TiO_2 layer with "Ni-free" zone on NiTi surface. It was found that PVP was covalently bonded on NiTi surface to create a hydrophilic layer for inhibiting protein adsorption on the surface. The present work offers a green approach to introduce a bioorganic surface on metal and other polymeric or inorganic substrates by gamma irradiation. |
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| Keywords: | NiTi Poly (N-vinyl-2-pyrrolidone) Shape memory alloy Surface modification Irradiation Protein adsorption |
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