Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione |
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| Authors: | I H Hall R A Izydore R Simlot O T Wong |
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| Institution: | (1) Division of Medical Chemistry and Natural Products, School of Pharmacy, University of North Carolina, CB#7360 Beard Hall, 27599 Chapel Hill, North Carolina, USA;(2) Department of Chemistry, North Carolina Central University, 27 707 Durham, North Carolina, USA |
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| Abstract: | 1,2,4-Triazolidine-3,5-diones and the 3,5-isoxazolidinedione were, observed to be, potent inhibitors of rat lens aldose reductase activity. In vivo in streptozotocin-diabetic rats, selected agents at 20 mg/kg/day, orally for 21 days reduced significantly the sorbitol levels of rbc, lens and sciatic nerves, suggesting that these derivatives may have some usefulness to treat clinical complications of diabetes mellitus. |
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| Keywords: | Aldose reductase inhibitors 1 2 4-triazolidine-3 5-diones 3 5-isoxazolidinediones diabetes |
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