The kinetics of estrogen binding to rat α-fetoprotein |
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| Authors: | B A Keel T O Abney |
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| Institution: | (1) Department of Endocrinology, Medical College of Georgia, 30912 Augusta, Georgia, USA;(2) Present address: Department of Reproductive Medicine and Biology, University of Texas Medical School, PO Box 20708, 77025 Houston, Texas, USA |
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| Abstract: | Summary Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.This work was supported by NSF grant PCM-8109847 and by a Grant-in-Aid of Research from Sigma Xi, The Scientific Research Society. |
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