| 取代苯胺、苯酚对鲤鱼毒性的定量构效关系 |
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| 引用本文： | 袁星,袁晓凡,赵元慧. 取代苯胺、苯酚对鲤鱼毒性的定量构效关系[J]. 东北师大学报(自然科学版), 2001, 33(1): 70-73 |
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| 作者姓名： | 袁星 袁晓凡 赵元慧 |
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| 作者单位： | 东北师范大学环境科学系, |
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| 摘 要： | 测定了16种取代苯胺，苯酚化合物对鲤鱼96h的急性毒性，了中毒症状，根据受体学说，进行定量构效关系（QSAR）研究，建立了QSAR方程，结果表明，分配过程及有机物分子与细胞内分子间的上互作用是影响这两类化合物生物毒性的主要因素。
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| 关 键 词： | 取代苯胺 苯酚 急性毒性 结构－活性 鲤鱼 定量构效关系 |
| 文章编号： | 1000-1832(2001)01-0070-04 |
| 修稿时间： | 2000-09-25 |
QSAR of the toxicity of substituted anilines and phenols to carp |
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| YUAN Xing,YUAN Xiao-Fan,ZHAO Yuan-hui. QSAR of the toxicity of substituted anilines and phenols to carp[J]. Journal of Northeast Normal University (Natural Science Edition), 2001, 33(1): 70-73 |
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| Authors: | YUAN Xing YUAN Xiao-Fan ZHAO Yuan-hui |
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| Abstract: | The 96h-LC 50 values of 16 substituted anilines and phenols to carp have been determined. The toxic symptom was observed. According to the acceptor theory, the quantitative structure-activity relationship was studied and the QSAR equation was established. The result showed that the main effects on biological toxicity of anilines and phenols are the partition processes and the interaction of electrons between the molecules of organic chemicals and the molecules in cell. |
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| Keywords: | substituted anilines and phenols acute toxicity structure-activity |
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