| 电针和促进剂对胰岛素口腔黏膜渗透的影响 |
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| 引用本文： | 孙爽,王锐,吕邵娃,许东东,杜春雨,李生金,李永吉.电针和促进剂对胰岛素口腔黏膜渗透的影响[J].哈尔滨商业大学学报(自然科学版),2010,26(4):390-392. |
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| 作者姓名： | 孙爽 王锐 吕邵娃 许东东 杜春雨 李生金 李永吉 |
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| 作者单位： | 黑龙江中医药大学药学院,哈尔滨,150040 |
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| 基金项目： | 省青年科学技术专项基金，黑龙江中医药大学科研基金，黑龙江中医药大学大学生创新基金 |
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| 摘 要： | 研究在电针仪作用下不同吸收促进剂对胰岛素口腔黏膜渗透性的影响.测定在使用电针仪前后不同吸收促进剂对胰岛素透过家兔口腔黏膜的渗透系数及血糖降低情况.加入吸收促进剂可以增加胰岛素透过口腔黏膜的渗透作用,使用电针仪后渗透作用显著提高.电针仪可协助吸收促进剂提高胰岛素口腔黏膜吸收.
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| 关 键 词： | 胰岛素 电针 口腔黏膜 促进剂 |
Comparison of effects of various absorption enhancers and EAA on buccal insulin delivery |
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| SUN Shuang,WANG Rui,LV Shao-wa,XU Dong-dong,DU Chun-yu,LI Sheng-jin,LI Yong-ji.Comparison of effects of various absorption enhancers and EAA on buccal insulin delivery[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2010,26(4):390-392. |
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| Authors: | SUN Shuang WANG Rui LV Shao-wa XU Dong-dong DU Chun-yu LI Sheng-jin LI Yong-ji |
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| Institution: | SUN Shuang,WANG Rui,LV Shao-wa,XU Dong-dong,DU Chun-yu,LI Sheng-jin,LI Yong-ji(School of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150040,China) |
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| Abstract: | To study the effects of various absorption enhancers on insulin permeation by EAA.The penetration of insulin through rabbit buccal membrane is investigated by measuring in vitro by EAA.Buccal insulin absorption is estimated in vivo from the cumulative response of serum glucose concentrations by EAA and comparison is made with the results of subcutaneous experiments.There is a statistically significant permeability increase of insulin over controls after using EAA.The result show that with the absorption enh... |
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| Keywords: | insulin EAA mouth mucosa absorption enhancers |
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