| 甲基杀虫脒盐酸盐在小鼠体内致突变研究 |
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| 引用本文： | 周启浩,王惠苏,郑景辉,司徒国坚,黄伯俊.甲基杀虫脒盐酸盐在小鼠体内致突变研究[J].暨南大学学报,1988(2). |
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| 作者姓名： | 周启浩 王惠苏 郑景辉 司徒国坚 黄伯俊 |
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| 作者单位： | 暨南理医卫生学教研室，暨南理医卫生学教研室，暨南理医卫生学教研室，暨南理医卫生学教研室，暨南理医卫生学教研室 |
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| 摘 要： | 甲基杀虫脒盐酸盐作为一种化学诱变物具有一定致突变性。本研究设计中突变的最低剂量组1/50LD50=4.48mg/kg体重,在小鼠骨髓细胞微核出现率中,与对照组比较,呈极显著性差异。因此,无作用剂量组应低于4.5mg/kg体重。染色体畸变的最低剂量在1/5LD50与阴性对照组有极显著性差异,染色体畸变的无作用剂量在8.95～44.76mg/kg范围内。
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| 关 键 词： | 甲基杀虫脒 毒性试验 小鼠 突变 染色体畸变 |
THE MUTAGENIC STUDY ON MICE EXPOSED TO CHIORDIMEFORM HYDROCHLORIDE |
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| Zhou Qihao Wang Huisu Zheng Jinghui Shitu Guojian.THE MUTAGENIC STUDY ON MICE EXPOSED TO CHIORDIMEFORM HYDROCHLORIDE[J].Journal of Jinan University(Natural Science & Medicine Edition),1988(2). |
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| Authors: | Zhou Qihao Wang Huisu Zheng Jinghui Shitu Guojian |
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| Abstract: | The micronucleus and chromosome aberration assay in mouse bone marrow cells were made for the Chlordimeform hydrochloride. This pesticide can induce mutation in some degrees. In our study the lowest dose group inducing mutation is 1/50LD50 (4.48mg/kg B. W). Comparing with the control group, the micronucleus rate in mouse bone marrow cells presented high significance. Therefore, non-reactive dose should be lower than 4.5mg/kg B. W. The lowest dose of chromosome aberration is 1/5LD50 and showed high significance comparing with the negative control group. The non-reative dose of chromosome aberration is in the range from 8.95mg/kg to 44.76mg/kg. |
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| Keywords: | Chiordimeform Toxicity Mice Mutagenic Chromosome aberration |
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