Synaptosomal adenosine triphosphatase (ATPase) inhibition by organophosphates |
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Authors: | H R Brown R P Sharma |
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Institution: | (1) Toxicology Program, Department of Veterinary Science, Utah State University, 84322 Logan, Utah, USA |
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Abstract: | Summary Chicken spinal cord adenosine triphosphatases (both Na+, K+ stimulated and ouabain insensitive) were inhibited by tri-o-tolyl phosphate (TOTP, a neurotoxic organophosphate which is not a cholinesterase inhibitor) and mevinphos (a non-neurotoxic compound but inhibitor of cholinesterases). The inhibition was concentration and time dependent, with an initial rapid drop in activity followed by a gradual exponential decline. |
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