Bioavailability of progesterone enhanced by intranasal spraying |
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Authors: | G F X David C P Puri T C Anand Kumar |
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Institution: | (1) World Health Organization Collaborating Centre for Research & Training in Human Reproduction, Experimental Biology Unit, All India Institute of Medical Sciences, 110029 New Delhi, India |
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Abstract: | Summary The bioavailability of progesterone (P) in terms of area under time-concentration curve and maximal concentration in the serum and cerebrospinal fluid was studied in adult ovariectomized rhesus monkeys following the administration of P as a nasal spray, i.v. or i.m. injections, nasal or eye drops. The bioavailability of P in both the body fluids was found to be considerably higher following its being sprayed intranasally.This work was supported by the World Health Organization, Geneva. |
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