Mutagenicity of melanin from human red hair |
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| Authors: | Z. P. Harsanyl P. W. Post Jeannie P. Brinkmann M. R. Chedekel Rose Marie Deibel |
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| Affiliation: | (1) Departments of Microbiology and Medicine (Dermatology Division), Cornell University Medical College, 1300 York Avenue, 10021 New York, New York, USA;(2) Department of Field ofGenetics, Cornell University Medical College, 1300 York Avenue, 10021 New York, New York, USA;(3) Department of Chemistry, The Ohio State University, 140 West 18th Avenue, 43210 Columbus, Ohio, USA |
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| Abstract: | Summary TheSalmonella typhimurium histidine reversion test of Ames et al. was used to demonstrate that pheomelanin, the red-brown polymeric pigment produced in human skin and hair, becomes mutagenic after exposure to long wave-length UV-light; a finding consistent with the UV-induced somatic mutation hypothesis for the origin of freckles and the high susceptibility of redheads and blonds to sunlight-induced skin cancers.Acknowledgments.S. typhimurium strains were kindly provided by Dr Bruce N. Ames. Z. Harzanyi was supported by NIEHS grant 00675-03 and an Andrew W. Mellon Teacher-Scientist Award. M. Chedekel thanks The Ohio State University Graduate School for financial assistance. |
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