Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat |
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| Authors: | A Gutnisky P Glikman M F Gimeno A L Gimeno |
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| Institution: | (1) Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) de la República Argentina, Serrano 665/69, 1414 Buenos Aires, (Argentina) |
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| Abstract: | Summary The administration of 15(R)-15-methyl prostaglandin E2 (15(R)-15-M-PGE2) in vivo significantly diminished the uptake of59Fe into blood, spleen, liver, femur and dried intestine of rats, whereas acetylsalicylic acid (ASA) increased the counts significantly. This effect of ASA was counteracted by 15(R)-15-M-PGE2. It is suggested that prostaglandins (PGs) might play an important role in inhibiting iron absorption at the intestinal level.This work was supported by grant No.6638 from CONICET (Argentina). The technical assistance of Mrs María E. Castro and Norma Rizzo is gratefully acknowleged. |
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