颈动脉MRI成像的实验性研究

目的探讨MR／多序列（TOF、T1WI、T2WI、PDWI）技术显示正常兔颈总动脉方法的可行性及准确性。方法选择普通级雄性新西兰大白兔10只，肌注麻醉后分别对颈总动脉行多序列MRI扫描，完成扫描后以过量注射麻醉药的方法处死兔子取大体血管标本，测量其血管直径作为对照，即选取兔第三颈椎水平同一层面的血管标本及MRI图像，分别测量同一侧颈总动脉的血管直径作相关性分析；同时将T1WI、T2WI及TOF原始图像传人工作站，用MIP及MPR方法进行血管重建分析。结果MRI及病理标本测量血管直径的平均数值分别为（2．37±0．11）和（2．41±0．12）mm，两者相关性具有统计学差异。T1WI、T2WI及TOF的MIP及MPR重建图像质量佳，重复性好。结论联合运用MRI的多种序列成像技术及血管重建技术，可以准确及无创地评价新西兰兔的颈总动脉的直径，血管壁信号，为进一步建立兔颈动脉粥样硬化斑块模型奠定基础。

Experimental study of MRI on the carotid artery

Objective To explore the feasibility and accuracy of multi - series MRI imaging（TOF,T1W1, T2WI, PDWI） to show the carotid artery of rabbits. Methods l0 New Zealand rabbits underwent multi - contrast MRI scan and DSA respectively. The images of the same slice were compared and the diameter of the ipsilateral carotid artery was measured. At the same time, the source images of T1WI, T2WI and TOF were reconstructed by the means of MIP and MPR. Results The mean of diameter is （2.37 ± 0.11 ） nun measured by MRI and （2.41± 0.12） nun by pathology. The two measurements were highly correlated, with a correlation coefficient of 0.977 （ P 〈 0.01 ）. The reconstructed imagings is excellent. Conclusion Multi - series MRI is an noninvasive technology which can evaluate the diameter and characterize the wall signal of carotid artery accurately. Combined with vascular reconstruction technology, the new muhiseries MRI is a good way to diagnose atherosclerosis. In the conclusion, the new and promising technology will facilitate build an atherosclerotic animal model.