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Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon |
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| Authors: | W Clauss J E Dürr R Krattenmacher H Hörnicke W Van Driessche |
| Institution: | (1) Institut für Veterinärphysiologie, Freie Universität Berlin, Koserstr. 20, D-1000 Berlin 33 West;(2) Institut für Zoophysiologie, Universität Hohenheim, Garbenstr. 30, D-7000 Stuttgart 70, (Federal Republic of Germany);(3) Laboratorium voor Fysiologie, K.U.L., Campus Gasthuisberg, B-3000 Leuven, (Belgium) |
| Abstract: | Summary In vivo and in vitro studies showed that electrogenic sodium transport in rabbit distal colon is modulated by aldosterone. It varies in a circadian rhythm; the external synchronizer is the light-dark cycle. The site of regulation was found to be in the apical membrane of colonic epithelial cells, in which the number of conducting sodium-channels is increased by aldosterone. |
| Keywords: | Rabbit colon in vivo in vitro potential difference isotopes noise analysis sodium transport apical sodium channels plasma aldosterone |
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