Genetics of sleep and sleep disorders |
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Authors: | M Kimura J Winkelmann |
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Institution: | (1) Max Planck Institute of Psychiatry, Kraepelinstrasse 2 – 10, Munich, 80804, Germany;(2) Institute of Human Genetics, GSF, Munich, Germany;(3) Institute of Human Genetics, Technical University, Munich, Germany |
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Abstract: | Genetic factors affect sleep. Studies in twin pairs demonstrate that the strong hereditary influences on sleep architecture
and some sleep disorders are transmitted through families. Evidence like this strongly suggests that sleep regulation receives
significant influence from genetic factors. Although recent molecular technologies have revealed evidence that genetic traits
or gene products trigger particular changes in sleep electroencephalogram activity, we are still far from finding candidate
genes or multiple mutations responsible for individual sleep disorders. Sleep is a very complex phenotype. Genetic susceptibility
and environmental factors should be also considered as contributors to sleep phenotype. The aim of this review is to present
a current summary and future prospects for genetic studies on sleep and selected sleep-associated disorders.
An erratum to this article is available at . |
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Keywords: | Chromosome familial sleep disorders electroencephalography (EEG) genotype heritability inbread mice mutations polymorphism |
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