Effect of ouabain on volume regulation of rabbit kidney cortex slices in hypo-osmotic media |
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Authors: | R Gilles C Duchêne I Lambert |
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Institution: | (1) Laboratory of Animal Physiology, University of Liège, 22, quai Van Beneden, B-4020 Liège, Belgique |
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Abstract: | Summary The volume regulation process at work in rabbit kidney cortex slices submitted to hypo-osmotic media show both a swelling limitation and a volume readjustment phase. Swelling limitation is Na+ dependent and is blocked by ouabain 10–3 M. There is, however, no need to implicate the activity of a ouabain sensitive Na+/K+ pump in this process.This work has been aided by a grant 1.5.422.82F from the FNRS to R.G. We wish to thank Mr J.M. Theate for his skilful assitance. |
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