| 基于分层网络和反馈机制的细胞重编程 |
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| 引用本文： | 刘仕进,刘艳伟,王瑞琦.基于分层网络和反馈机制的细胞重编程[J].上海大学学报(自然科学版),2016,22(5):552-559. |
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| 作者姓名： | 刘仕进 刘艳伟 王瑞琦 |
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| 作者单位： | 上海大学理学院, 上海 200444 |
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| 摘 要： | 在多潜能细胞分化并最终形成相应的谱系结构的过程中, 多潜能细胞可能发生重编程.主要研究细胞分化过程中由双重负反馈回路的层级网络如何产生细胞重编程. 通过建立数学模型对整个系统的分叉进行分析, 揭示分层网络以及反馈机制产生细胞重编程的机理.
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| 关 键 词： | 反馈调控 分层网络 分叉分析 细胞重编程 |
| 收稿时间： | 2016-02-23 |
Cell reprogramming based on hierarchical networks and feedback mechanism |
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| LIU Shijin,LIU Yanwei,WANG Ruiqi.Cell reprogramming based on hierarchical networks and feedback mechanism[J].Journal of Shanghai University(Natural Science),2016,22(5):552-559. |
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| Authors: | LIU Shijin LIU Yanwei WANG Ruiqi |
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| Institution: | College of Sciences, Shanghai University, Shanghai 200444, China |
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| Abstract: | The process that pluripotent cells differentiate and finally commit to certain cell lineages originates from stem cells. It is performed with a series of cellfate decisions driven by pluripotent progenitors. Reprogramming of pluripotent cells can occur in this process. Focusing on the cell differentiation and presenting a hierarchical network with double negative feedbacks, the reprogramming strategy in the pathways of cell differentiation can be induced by integrated influence of a hierarchical network and the feedback regulatory mechanisms. |
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| Keywords: | feedback regulatory hierarchical network bifurcation analysis cell reprogramming |
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