干细胞与心肌再生

由于成年心肌细胞通常不能再生，严重的心肌损伤会导致心肌不可逆的重构坏死, 从而发生心功能失调. 干细胞再生治疗为心肌再生提供了很好的策略. 为了寻找合适的干细胞类型, 促进心肌再生, 有效改善心功能, 需要更好地了解心肌修复和再生的分子基础. 已有研究发现多种干细胞可促进心肌再生. 描述了骨髓干细胞的促血管新生及心肌分化的能力在心梗治疗中的作用, 还讨论了心脏侧群干细胞以及诱导型多能干细胞在心肌再生中的作用和分子机制. 所阐述的最新数据有利于拓展干细胞治疗的有效潜能及临床影响.

Stem cells and cardiac regeneration

Human myocardium has poor regenerative power, and significant myocardial injury results in irreversible damage, remodeling, and dysfunction. Stem cells enable promising regenerative strategies for cardiovascular diseases. The search for suitable stem cell phenotypes that will improve myocardial regenerative ability needs better understanding of the molecular mechanisms of repair and regeneration. Previous reports have suggested that several stem phenotypes regulate myocardial regeneration in vitro and in vivo. This review describes the therapeutic potential of mesenchymal stem cell (MSC) therapy in terms of angiogenic and regenerative capacity after myocardial infarction. In addition, the effect of cardiac side population cells (CSPs) and the differentiation of induced pluripotent stem cells (iPSCs) in cardiac regeneration are discussed. The review provides recent data and helps broaden therapeutic potential and clinical impact of stem cell therapy.