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Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis |
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| Authors: | K Iwase-Okada K Kojima T Kato H Kaku T Okazaki K Wago S Sakakibara T Nagatsu |
| Institution: | (1) Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, 227 Yokohama, Japan;(2) Kanagawa Rehabilitation Center, Nakazawa Hospital, 243-01 Atzugi, Kanagawa, Japan;(3) Mihono Rehabilitation Hospital, 031 Hachinohe, Aomori, (Japan);(4) Peptide Institute, Protein Research Foundation, 562 Minoh, Osaka, Japan |
| Abstract: | Summary The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methyl-coumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of peptides derived from collagen. A significant positive correlation was observed between the activities of the two serum peptidases. |
| Keywords: | Rheumatoid arthritis peptidase collagen-like |
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