|
|||||
|
|
| 新型3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲酰胺类化合物的合成 | |
| 引用本文： | 张应鹏,郑毅,王俊芳,窦花妮,杨云裳. 新型3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲酰胺类化合物的合成[J]. 兰州理工大学学报, 2011, 37(1): 63-66 |
| 作者姓名： | 张应鹏 郑毅 王俊芳 窦花妮 杨云裳 |
| 作者单位： | 1. 兰州理工大学石油化工学院,甘肃,兰州,730050 2. 兰州理工大学石油化工学院,甘肃,兰州,730050;浙江省化工研究院,浙江,杭州,310023 3. 浙江省化工研究院,浙江,杭州,310023 |
| 基金项目： | 浙江省自然科学基金(Y3080068) |
| 摘 要： | 以2,3-二氯吡啶为起始原料经过肼解、与马来酸二乙酯成环、溴代、氧化、水解得到关键中间体3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲-1-甲酸,然后再与二氯亚砜反应生成甲酰氯,最后与各种环氨作用得到最终化合物3-溴-1-(3-氯-2-吡啶)-1H-吡唑甲酰胺类化合物,并对最终化合物进行表征. |
| 关 键 词： | 吡啶基吡唑羧酸 环氨 合成 |
Synthesis of novel 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid amide compounds1 |
|
| ZHANG Ying-peng,ZHENG Yi,WANG Jun-fang,DOU Hua-ni,YANG Yun-shang. Synthesis of novel 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid amide compounds1[J]. Journal of Lanzhou University of Technology, 2011, 37(1): 63-66 | |
| Authors: | ZHANG Ying-peng ZHENG Yi WANG Jun-fang DOU Hua-ni YANG Yun-shang |
| Affiliation: | ZHANG Ying-peng1,ZHENG Yi1,2,WANG Jun-fang1,DOU Hua-ni2,YANG Yun-shang1(1.College of Petrochemical Engineering,Lanzhou Univ.of Tech.,Lanzhou 730050,China,2.Zhejiang Chemical Industry Research Institute,Hangzhou 310023,China) |
| Abstract: | Taking 2,3-dichloropyridine as raw material,the key intermediate 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid was obtained by means of hydrazining,diethyl maleate,ester-bromination,oxidation,and hydrolysis first.Then the carbonyl chloride was synthesized with dichloro sulfoxide.Finally,the 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid ammide compounds were synthesized with carbonyl chloride reacting with ring ammonia.The final compounds were characterized. |
| Keywords: | pyridyl-pyrazole-5-carboxylic acid ring ammonia synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |