Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis |
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| Authors: | M Tsukano M Kotani K Matsuno K Miyakawa Y Nawa |
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| Institution: | (1) Department of Anatomy, Kumamoto University Medical School, Kumamoto, (Japan);(2) Department of Anatomy, Kumamoto University Medical School, 2-2-1 Honjo, 860 Kumamoto, Japan |
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| Abstract: | Summary The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.Acknowledgments. We are grateful to The Naito Foundation Research Grant for 1983. |
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| Keywords: | Adjuvant arthritis unresponsiveness suppressor cells sex difference testosterone |
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