Influence of cyclic nucleotides on protein synthesis in vascular smooth muscle |
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| Authors: | R. G. G. Andersson H. J. Arnqvist L. Lundholm |
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| Affiliation: | (1) Department of Pharmacology, Linköping University, Regionsjukhuset, S-518 85 Linköping, Sweden |
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| Abstract: | Summary The incorporation of leucice-14C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10–3M) and decreased by cyclic AMP (10–3M). There was no effect of 5 AMP (10–3M). The phosphodiesterase inhibiting drugs theophylline (10–3M) and papaverine (5×10–5 g/ml) both decreased the leucine-14C incorporation.We are indebted to Mrs.Lena Burlin for hear assistance. Finacial support has been provided by the Swedish State Medical Research Council (No. 04X-101X-4498). |
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