|
|||||
|
|
Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls |
|
| Authors: | Sklar P Schwab S G Williams N M Daly M Schaffner S Maier W Albus M Trixler M Eichhammer P Lerer B Hallmayer J Norton N Williams H Zammit S Cardno A G Jones S McCarthy G Milanova V Kirov G O'Donovan M C Lander E S Owen M J Wildenauer D B |
| Institution: | Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. sklar@genome.wi.mit.edu |
| Abstract: | A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |