Ultrastructural visualization of Cabot rings in pernicious anemia |
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| Authors: | L Kass R H Gray |
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| Institution: | (1) Department of Internal Medicine, Simpson Memorial Institute, Medical School, 48109 Ann Arbor, Michigan, USA;(2) The Cellular Chemistry Laboratory, Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, 48109 Ann Arbor, Michigan, USA |
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| Abstract: | Summary Using the ammoniacal silver stain, Cabot rings were identified in peripheral blood erythrocytes from patients with severe untreated pernicious anemia. Ultrastructural studies of these erythrocytes showed silver deposits in partial loops and figure-eight forms, indicating that arginine rich histone may be a prominent component of the Cabot ring.Supported in part by the Elizabeth Roodvoets Memorial Grant for Cancer Research of the American Cancer Society (No. CI-79) and by National Cancer Institute Grant USPHS No. CA 14428-02. |
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