| Effects of short-term IOP elevation on receptive field properties of cat LGN cells |
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| 引用本文： | TAOLiming ZHANGNan YEXiang ZHOUYifeng. Effects of short-term IOP elevation on receptive field properties of cat LGN cells[J]. 科学通报(英文版), 2004, 49(12): 1250-1253. DOI: 10.1360/04wc0070 |
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| 作者姓名： | TAOLiming ZHANGNan YEXiang ZHOUYifeng |
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| 作者单位： | [1]VisionResearchLaboratory,UniversityofScienceandTechnologyofChina,Hefei230027,China [2]VisualInformationProcessingLaboratory,InstituteofBiophysics,ChineseAcademyofSciences,Beijing100101,China |
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| 摘 要： | To investigate the effects of short-term intraocular pressure (IOP) elevation on the receptive field properties of lateral geniculate nucleus (LGN) cells, responses of the LGN cells to annulus, disc and drifting gratings with high or low spatial frequencies have been recorded extracellularly in the eat with the retinal perfusion pressure kept stable (30mmHg). Our results indicated that the responses of the X and Y type LGN cells were significantly weakened during IOP elevation. And the responses varied with the different mechanisms of receptive fields. Specifically, while using annulus and disc as stimuli, the responses of Y cells were more tolerant than X cells to lOP elevation. The surround area of the receptive field was more sensitive to lOP elevation than the center. The mean responses during IOP elevation decreased more than the peak responses did. lOP elevation has more influence on the responses of X cells than on the response of Y cells to the drifting gratings with high spatial frequency. These results may reflect different degrees of ischemia on corresponding retinal structures caused by IOP elevation.
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| 关 键 词： | 眼内压 侧向膝状核 视网膜 青光眼 视神经退化 IOP LGN 猫 |
| 收稿时间： | 2004-02-17 |
| 修稿时间： | 2004-05-11 |
Effects of short-term IOP elevation on receptive field properties of cat LGN cells |
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| Tao Liming,Zhang Nan,Ye Xiang,Zhou Yifeng. Effects of short-term IOP elevation on receptive field properties of cat LGN cells[J]. Chinese science bulletin, 2004, 49(12): 1250-1253. DOI: 10.1360/04wc0070 |
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| Authors: | Tao Liming Zhang Nan Ye Xiang Zhou Yifeng |
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| Affiliation: | TAO Liming1,2, ZHANG Nan1, YE Xiang1 & ZHOU Yifeng1,3 1. Vision Research Laboratory, University of Science and Technology of China, Hefei 230027, China; 2. Department of Ophthalmology, First Affiliated Hospital, Anhui Medi- cal University, Hefei 230022, China; 3. Visual Information Processing Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | To investigate the effects of short-term intra- ocular pressure (IOP) elevation on the receptive field proper- ties of lateral geniculate nucleus (LGN) cells, responses of the LGN cells to annulus, disc and drifting gratings with high or low spatial frequencies have been recorded extracellularly in the cat with the retinal perfusion pressure kept stable (30 mmHg). Our results indicated that the responses of the X and Y type LGN cells were significantly weakened during IOP elevation. And the responses varied with the different mechanisms of receptive fields. Specifically, while using an- nulus and disc as stimuli, the responses of Y cells were more tolerant than X cells to IOP elevation. The surround area of the receptive field was more sensitive to IOP elevation than the center. The mean responses during IOP elevation de- creased more than the peak responses did. IOP elevation has more influence on the responses of X cells than on the re- sponse of Y cells to the drifting gratings with high spatial frequency. These results may reflect different degrees of ischemia on corresponding retinal structures caused by IOP elevation. |
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| Keywords: | intraocular pressure (IOP) lateral geniculate nucleus (LGN) retina glaucoma cat. |
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