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The effect of photodynamic therapy on tumor angiogenesis
Authors:Ramaswamy Bhuvaneswari  Yik Yuen Gan  Khee Chee Soo  Malini Olivo
Institution:(1) National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore;(2) Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore, 637616, Singapore;(3) Singapore Bioimaging Consortium, Biomedical Sciences Institutes, 11 Biopolis Way, #02-02 Helios, Singapore, 138667, Singapore;(4) Department of Pharmacy, National University of Singapore, No. 18 Science Drive 4, Block S4, Singapore, 117543, Singapore
Abstract:Photodynamic therapy (PDT), the activation of a photosensitive drug in tumor tissue with light of specific wavelength, has been used effectively to treat certain solid tumors. Though therapeutic responses are encouraging, PDT-mediated oxidative stress can act as an angiogenic switch that ultimately leads to neovascularization and tumor recurrence. This article explores the effect of PDT on angiogenesis in different tumor models. Overexpression of proangiogenic vascular endothelial growth factor, cyclooxygenase-2 and matrix metalloproteases has often been reported post-illumination. Recent clinical studies have demonstrated that inhibiting angiogenesis after chemotherapy and radiotherapy is an attractive and valuable approach to cancer treatment. In this review, we report the effective therapeutic strategy of combining angiogenesis inhibitors with PDT to control and treat tumors.
Keywords:Angiogenesis  Photodynamic therapy (PDT)  Cancer  Vascular endothelial growth factor (VEGF)  Cyclooxygenase-2 (COX-2)  Angiogenic inhibitors
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