| N-乙酰-D-氨基葡萄糖的研制 |
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| 引用本文： | 何新益,殷七荣,杨国金.N-乙酰-D-氨基葡萄糖的研制[J].湖南文理学院学报(自然科学版),2001,12(4):63-65. |
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| 作者姓名： | 何新益 殷七荣 杨国金 |
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| 作者单位： | 湖南金健米业股份有限公司 湖南 常德 415000
(何新益，殷七荣)，湖南金健米业股份有限公司 湖南 常德 415000(杨国金) |
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| 摘 要： | 研究了以氨基葡萄糖盐酸盐（ＧＡＨ）为原料、乙酸酐为酰化剂制备了Ｎ-乙酰-Ｄ-氨基葡萄糖（ＮＡＧ）。着重考察了反应时间、酰化剂量、ｐＨ值以及溶剂极性对Ｎ-乙酰化反应的影响。同时通过一系列的纯化处理，得到了ＮＡＧ精制品。研究结果表明：反应时间影响较小；当Ｍ（ＮＨ２）：Ｍ（Ａｃ２Ｏ）＝１：４，在吡啶为溶剂的碱性环境下Ｎ-乙酰化反应得率较高，达７０％。ＮＡＧ精制品的结构通过红外图谱、熔点等进行确证。
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| 关 键 词： | NAG GAH N-乙酰化反应 |
| 文章编号： | 1009-3818(2001)04-0063-03 |
| 修稿时间： | 2001年5月16日 |
THE PRODUCTION OF N-ACETYL-D-GLU COSAMINE |
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| HE Xin-yi,YIN Qi-rong,YANG Guo-jin.THE PRODUCTION OF N-ACETYL-D-GLU COSAMINE[J].Journal of Hunan University of Arts and Science:Natural Science Edition,2001,12(4):63-65. |
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| Authors: | HE Xin-yi YIN Qi-rong YANG Guo-jin |
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| Abstract: | The preparation of N-acetyl-D-glucosamine (N AG) by D-glucosamine hydrochloride (GAH) and acetic anhydride was studied.The ef fect of reaction time, pH, the dosage of acetic anhydride and different solution on N-acetyl reaction were discussed. Through a series of purifica tion, the purified product was attained. The result indicated that reaction time showed litter effect. The yield of NAG reached to 70% on the condition that the ratio of NH2 to AC2O was 1:4 under pyrrlcoline solution. The structure of purified product was characterized by IR., Melting point et al., which showed the product was NAG. |
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