The interaction of warfarin with antacid constituents in the gut |
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| Authors: | J C McElnay D W G Harron P F D'Arcy P S Collier |
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| Institution: | (1) Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL Belfast, N. Ireland |
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| Abstract: | Summary A study was made of the effect of 4 constituents of antacid preparations on the absorption of the coumarin derivate warfarin sodium using an in vitro experimental model. The constituents tested were activated dimethicone (a silicone) magnesium trisilicate, bismuth carbonate and the adsorbant, kaolin. Slight decreased intestinal absorption was shown by magnesium trisilicate (19%) and bismuth carbonate (7%), the other 2 components showing no effects. |
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