Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities |
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| Authors: | H. Vapaatalo Inge-Britt Lindén T. Metsä-Ketelä M. Kangasaho K. Laustiola |
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| Affiliation: | (1) Department of Biomedical Sciences, University of Tampere, SF-33101 Tampere 10;(2) Research Laboratories of Medica Ltd, SF-00510 Helsinki 51, (Finland) |
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| Abstract: | Summary Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1–0.5 mM, but inhibited by higher concentrations.Acknowledgment. Supported by a grant from the Orion and Medica Scientific Foundation, Finland. |
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