Increased angiogenesis in diabetes |
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Authors: | K. Norrby A. Jakobsson M. Simonsen J. Sörbo |
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Affiliation: | (1) Department of Pathology, Gothenburg University, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden |
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Abstract: | Summary Rats with streptozotocin-induced diabetes mellitus showed a 3.4–4.5 times increased angiogenic response following mast-cell activation in situ as compared with age-matched normal controls. The test tissue used was the mesenteric window, which we have previously exploited as a quantitative angiogenesis assay. In the present study two idependent techniques for quantifying the angiogenic response showed essentially the same result. The finding of a pathologically increased angiogenic reaction in the diabetic animals is noteworthy since some of the most harmful complications of diabetes in man relate to proliferative vascular lesions. |
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Keywords: | Angiogenesis diabetes mast cells mesentery quantification rat |
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