Spontaneously (genetic) hypertensive rats: Naloxone-reversible and propranolol-reversible decrease in pain sensitivity |
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| Authors: | J. M. Saavedra |
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| Affiliation: | (1) Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20205 Bethesda, Maryland, USA |
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| Abstract: | Summary Adult spontaneously hypertensive rats (SHR) are less sensitive to painful stimuli than their normotensive controls, Wistar-Kyoto (WKY) rats. This difference can be eliminated by the specific opiate antagonist, naloxone, and by the  -adrenergic blocking agent, propranol.Acknowledgment. The author wishes to thank Miss R. L. Holcomb for her editorial assistance. |
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