ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE |
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Authors: | T. Watanabe A. Morimoto Y. Sakata N. Murakami |
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Affiliation: | (1) Department of Physiology, Yamaguchi University School of Medicine, 755 Ube Yamaguchi, (Japan) |
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Abstract: | Summary We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 (IL-1). The present results show that ACTH responses induced by intravenous injection of IL-1 were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2. |
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Keywords: | Hypothalamus interleukin-1 prostaglandin corticotropin releasing factor ACTH acute phase response |
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