红树植物内生真菌Nigrospora sphaerica的次级代谢产物研究

对红树植物木果楝来源内生真菌Nigrospora sphaerica进行了次级代谢产物研究.综合运用硅胶柱层析、重结晶、分析型和半制备型高效液相色谱等现代色谱学和化学方法对其大米发酵产物进行了分离纯化，从中分离得到了10个化合物，并根据化合物的光谱数据和理化性质鉴定了其化学结构分别为：bis-(2-ethylhexyl)-phthalate (1)，邻苯二甲酸二丁酯 (2),1-phenyl-1,2-ethanediol (3)，tyrosol (4)，单乙酸甘油酯 (5)， R-mevalonolactone (6)，甘露醇 (7)，D-吡喃葡萄糖 (8)，亚油酸 (9),3-methylbut-2-enyl-4-hydroxybenzoate (10).除化合物4外，其余化合物均为首次从该菌种中分离得到.

Secondary metabolites from mangrove endophytic fungi Nigrospora sphaerica

The secondary metabolites of the endophytic fungus Nigrospora sphaerica from mangrove plants Xylocapus granatum were studied. The metabolites of rice fermented by Nigrospora sphaerica were purified by modern chromatography and chemical methods， including silica gel column， analytical and semi-preparative HPLC. Then their structures were elucidated by means of physical and chemical properties， spectroscopic analysis， together with comparison with the reported literatures. Ten compounds were isolated and identified as bis-(2-ethylhexyl)-phthalate (1)，dibutyl phthalate (2),1-phenyl-1,2-ethanediol (3)，tyrosol (4)，gylcerol monoacetate (5)，R-mevalonolactone (6)，D-mannitol (7)，D-glucose (8)，linoleic acid (9),3-methylbut-2-enyl-4-hydroxybenzoate (10). Except for compound 4， all the rest compounds were obtained from Nigrospora sphaerica for the first time.