Effects of puromycin on rat embryos in vitro |
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| Authors: | T J Flynn L Friedman T N Black |
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| Institution: | (1) Division of Toxicology, Food and Drug Administration, 20204 Washington, D.C., USA |
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| Abstract: | Summary Somite-staged rat embryos were exposed to varying concentrations of puromycin for 48 h in vitro. Medium concentrations below 0.92  M had no significant effects, while concentrations above 1.84 M were lethal. Between these extremes, there were concentration dependent increases in the incidence of malformations in a close relationship to growth retardation. |
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| Keywords: | Rat embryo in vitro puromycin microbial toxin teratogenicity lipids |
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