The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation

Summary The cellular and subcellular distribution of ³H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.Acknowledgment. The authors are most grateful to Mr and Mrs Gudelsky for their generous support.