| 2-氨基-N-(2,2,2-三氟乙基)乙酰胺的合成 |
| |
| 引用本文： | 黄道友,江国栋,李立威,王勇,胡建梅,王寒寒,李强,袁颂东. 2-氨基-N-(2,2,2-三氟乙基)乙酰胺的合成[J]. 安徽大学学报(自然科学版), 2017, 41(5). DOI: 10.3969/j.issn.1000-2162.2017.05.015 |
| |
| 作者姓名： | 黄道友 江国栋 李立威 王勇 胡建梅 王寒寒 李强 袁颂东 |
| |
| 作者单位： | 湖北工业大学化学化工学院,湖北武汉,430068;荆楚理工学院化工与药学院,湖北荆门,448000 |
| |
| 基金项目： | 湖北省教育厅科学技术中青年人才项目，荆楚理工学院博士人才科研启动基金资助项目，湖北省自然科学基金创新群体重点资助项目 |
| |
| 摘 要： | 在低温和碱性条件下,将甘氨酸与碳酸二叔丁酯反应制得N-(叔丁氧羰基)甘氨酸化合物(1).再将化合物1在N,N’-二环己基碳化二亚胺和4-二甲氨基吡啶的作用下与三氟乙胺盐酸盐进行酰胺化制得N-[2-氧代-2-[(2,2,2-三氟乙基)氨基]乙基]氨基甲酸-1,1-二甲基乙酯(2).然后将化合物2在盐酸作用下脱除保护基Boc,得到2-氨基-N-(2,2,2-三氟乙基)乙酰胺.最后通入氯化氢气体制成2-氨基-N-(2,2,2-三氟乙基)乙酰胺盐酸盐(3).化合物1~3经MS、IR、1 H NMR和13 C NMR等确证结构.文中所采用的方法具有原料易得、操作简便、安全性高等优点.
|
| 关 键 词： | 甘氨酸 2氨基-N-(2,2 2-三氟乙基)乙酰胺 fluralaner 合成 结构确证 |
The synthesis of 2-amino-N-(2,2,2-trifluoroethyl) acetamide |
| |
| HUANG Daoyou,JIANG Guodong,LI Liwei,WANG Yong,HU Jianmei,WANG Hanhan,LI Qiang,YUAN Songdong. The synthesis of 2-amino-N-(2,2,2-trifluoroethyl) acetamide[J]. Journal of Anhui University(Natural Sciences), 2017, 41(5). DOI: 10.3969/j.issn.1000-2162.2017.05.015 |
| |
| Authors: | HUANG Daoyou JIANG Guodong LI Liwei WANG Yong HU Jianmei WANG Hanhan LI Qiang YUAN Songdong |
| |
| Abstract: | Compound 1 was synthesized by the reaction of glycine with (Boc)2O under low temperature and alkaline conditions.Compound 2 was obtained by acylation of compound 1 with 2,2,2-trifluoroethylamine hydrochloride in dichloromethane,using DCC as coupling agent and DMAP as catalyst.Reaction of compound 2 with hydrochloric acid to remove the protecting group Boc to give 2-amino-N-(2,2,2-trifluoroethyl) acetamide,and then was treated with hydrogen chloride gas to produce the hydrochloride salt 3.All compounds 1-3 were fully characterized by MS,IR,1H NMR and 13C NMR.The method is easy to operate,has high safety and the raw materials are easily obtained. |
| |
| Keywords: | glycine 2-amino-N-(2,2,2-trifluoroethyl) acetamide fluralaner synthesis structurally characterized |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
