Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells |
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| Authors: | T Ochi T Kaise Y Oya-Ohta |
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| Institution: | (1) Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 199-01 Sagamiko, Kanagawa;(2) Kanagawa Prefectural Public Health Laboratories, Nakao-cho 52-2, Asahi-ku, 241 Yokohama;(3) Kanagawa Prefectural College of Nursing and Medical Technology, Nakao-cho 50-1, Asahi-ku, 241 Yokohama, Japan |
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| Abstract: | The cytotoxicity of arsenic compounds towards BALB/c 3T3 cells in culture was investigated, together with the role of glutathione (GSH) in the induction of the cytotoxic effects. The rank order of cytotoxicity was as follows: arsenite (As3+)>arsenate (As5+)>dimethylarsinic acid (DMAA)>methylarsonic acid (MAA)>trimethylarsine oxide (TMAO). Arsenobetaine, arsenocholine and the tetramethylarsonium ion were less toxic. Depletion of GSH enhanced the cytotoxic effects of As3+, As5+, MAA and TMAO, while the cytotoxicity of DMAA was markedly reduced by depletion of GSH. These results suggest that GSH plays a role in protecting the cells against the toxic effects of As3+, As5+, MAA and TMAO while it is involved in the induction of the cytotoxic effects of DMAA. |
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| Keywords: | Arsenic compounds cytotoxicity BALB/c 3T3 cells glutathione depletion |
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