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Free radicals produced in a nitrosofluorene-unsaturated lipid reaction
Authors:Robert A Floyd
Institution:(1) Biomembrane Research Laboratory, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, 73104 Oklahoma City, Oklahoma, USA
Abstract:Summary We report here the first demonstration that the carcinogen 2-nitrosofluorene reacts directly with lipid molecules containing carbon-carbon double bonds to yield free radicals which appear to be the nitroxyl free radical of the carcinogen covalently bound to the lipid.This investigation was supported in part by the U.S. Public Health Service Grant 5 RO1 CA18591-01 from the National Institutes of Health.
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