An actin-destabilizing factor is present in human plasma |
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| Authors: | C Chaponnier R Borgia E Rungger-Brändle R Weil G Gabbiani |
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| Institution: | (1) Departments of Pathology and Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland |
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| Abstract: | Summary Plasma and serum of humans or experimental animals contain a factor which destabilizes F-actin. The factor has no DNAse or thrombin activity and after incubation with F-actin does not modify the position of the actin band on a SDS polyacrylamide gel. Hence it probably depolymerizes F-actin.Acknowledgment. This work was supported by the Swiss National Science Foundation, grant No.3.692-0.76. We thank Drs M. Crippa and C.A. Bouvier for measuring the DNAse and thrombin activities. The technical help of Mrs M. Redard and A. De Almeida and the photographic work of Mr J.-C. Rumbeli and Mr E. Denkinger are gratefully acknowledged. |
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